Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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SmartKem, Inc.

Manchester, United Kingdom

We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (333-254904) of our report dated March 28, 2022 relating to the consolidated financial statements of SmartKem, Inc., which appears in the Annual Report on Form 10-K. Our report contains an explanatory paragraph regarding SmartKem, Inc.’s ability to continue as a going concern.

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/s/ BDO LLP

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BDO LLP

Manchester, United Kingdom

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March 28, 2022