Exhibit 23.1

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CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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SmartKem, Inc.

Manchester, United Kingdom

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We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (No. 333-269557, 333-264184, 333-254904) of our report dated March 30, 2023 relating to the consolidated financial statements of SmartKem, Inc., which appears in the Annual Report on Form 10-K. Our report contains an explanatory paragraph regarding SmartKem, Inc.’s ability to continue as a going concern.

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/s/ BDO LLP

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BDO LLP

Manchester, United Kingdom

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March 30, 2023